Senior Software Engineer (Python + AWS)

Project start: September 
100% remote

We're looking for a Senior Software Engineer to join the team building the Clinical Data Layer, a cloud-native platform that standardizes clinical trial data to the CDISC SDTM model at scale. You'll work across a Python/AWS backend and a React frontend, owning features end-to-end from data pipeline design through the analyst-facing spec authoring tool.

What You'll Do

• Design and extend the SDTM transformation engine — AWS Step Functions orchestration, Lambda workers, and Databricks write paths

• Build and evolve the GraphQL/AppSync API and React frontend used by analysts to author mapping specifications

• Own infrastructure-as-code changes across service Terraform stacks and shared infrastructure 

• Participate in code review, architecture discussions, and on-call rotation

• Mentor engineers newer to the stack or clinical data domain

What We're Looking For
Must-Have

• 5+ years of professional software engineering experience

• Python proficiency — you're comfortable with Lambda Powertools, pytest/pytest-bdd, and writing clean, testable Python in a monorepo context

• AWS depth: Lambda, Step Functions, S3, DynamoDB, and IAM — you can reason about cost, latency, and failure modes, not just get things working

Strong Plus

• GraphQL / AppSync experience — schema design, resolvers, and consuming AppSync from a React client

• React + TypeScript — comfortable contributing to a Vite/Cloudscape SPA without being a frontend specialist

• Infrastructure as code with Terraform — reading, writing, and debugging multi-stack configurations

• Databricks or similar large-scale data processing platforms

• Clinical data standards (CDISC SDTM, ADaM) or regulated-industry software development experience (GxP, 21 CFR Part 11)

• A good grasp of event-driven and distributed system patterns — fan-out/fan-in, idempotency, at-least-once delivery